We present the 15th Annual
Advances and Progress in Drug Design 2016, with a strong focus on advanced biophysical technologies and combinatorial methods enabling greater insight of biologics and drug interaction.
Hosted over two days, this international conference will provide an exclusive opportunity to gain new insight on small molecule-protein fragments, IMI Open PHACTS project for data mining work flows, and structure-based models combining hit finding strategies of fragment leads.
Inspiring talks will also highlight developments in the quality control of misfolded proteins, solvent effects, and protein-ligand stability; identifying whether the bound conformation of protein-ligand structure gives the lowest energy state and the impact of drug design.
Join us for a keynote address on reviving covalent drug design in oncology from Pfizer, and a case study session on target validation of NCE’s through fragment screening and opportunities for antibodies as guidance tools from UCB.
Benefits of Attending
Our 15th Annual
Drug Design Conference will focus on biophysical techniques to highlight advancements in modelling protein conformations and drug candidates.
Challenges to be discussed include:
- Calculating entropic/ enthalpic contributions of water
- Accounting for protein stability, solvability and evolutionary conformational changes
Furthermore, we will take a closer look at the dissociation rates of drugs:
- Factors that influence the rate of dissociation/association
- Selectivity between competing receptor sites on proteins and their effect on drug efficacy and protein stability
New for 2016:
- Biophysical screening methods for small molecule probes in structural elucidation
- Optimisation receptor binding kinetics
- Fragment deconstruction methods and
- Clinical evaluation of fragment-based drug leads
- In silico metabolic prediction of hERG toxicity
Plus Two Interactive Half-Day Post-Conference Workshops | Wednesday 17th February 2016
WORKSHOP A: A Fresh View on Molecular Recognition: The Dynamic PerspectiveWorkshop Leader: Dr. Xavier Barril, ICREA Research Professor, School of Pharmacy, Barcelona University
8.30am - 12.30pm
WORKSHOP B: Analysis and Application of Ligand Conformation in Drug DesignWorkshop Leaders: Dr. Emma Blaney, Senior Programme Manager, and Dr. Martin Watson, Head of NMR, C4X Discovery
1.30pm – 5.30pm
Speakers
- Alexander Hillisch, Director, Medicinal Chemistry, Bayer
- Alexey Rak, Head of Bio Structure & Biophysics, Sanofi
- Armin Ruf, Section Head Biostructure, Roche
- Atilla Ting, Computational Chemist, AstraZeneca
- Benjamin Tehan, Senior Computational Chemist, Heptares Therapeutics
- Doug Johnson, Research Fellow, Pfizer
- Gianni Chessari, Director, Astex Pharmaceuticals
- Gregg Siegal, Chief Executive Officer, ZoBio
- Hans Matter, Senior Scientist, Sanofi-Aventis
- Herman van Vlijmen, Senior Director, Janssen
- Howard Feldman, Principal Scientist, Chemical Computing Group
- Jordi Munoz Muriedas, Investigator, GSK
- Manuel Molina, Research Scientist, Eli Lilly
- Marta Westwood, Principal Scientist, UCB Pharma
- Matthias Frech, Director, Merck KGaA
- Mike Hann, Director, Computational & Structural Sciences, GlaxoSmithKline
- Paul Hawkins, Applications Science Group Leader, OpenEye Scientific Software
- Philippe Guedat, Chief Executive Officer, INFLECTIS BIOSCIENCE
- Simone Fulle, Research Group Leader, BioMed X Innovation Center
- Stevan Djuric, Senior Director, Abbott Labortories
- Xavier Barril, ICREA Research Professor, Barcelona University
Please fill in your name and email to receive the conference agenda of this event.
The agenda is available as PDF under downloads at the right side of the page.
Venue
Holiday Inn Kensington Forum
97 Cromwell Rd, Kensington, SW7 4DN
London, UK
Who Should Attend
Our 15th annual Advances and Progress in Drug Design Conference will build on the success of our previous events and bring together a unique mix of senior executives from all over industry and academia and will be an unrivalled forum for problem-solving discussion and debate.
This event is unmissable for VPs, Directors, Heads, Senior Managers and Pricnipal Scientists from the following departments:
- Structure and Informatics
- Computer-Aided Drug Design
- Computational Chemistry
- Cancer Research
- Molecular Interaction
- Medicinal Chemistry
- Pharmacology
- Molecular Imaging
- Neuroscience Chemistry
- Drug Discovery & Design
- Target Discovery
- Translational Sciences
- Biophysics
- Screening
- Clinical Development
- Structural Biology
- Crystallography
- Medicinal Chemistry
Venue
Holiday Inn Kensington Forum97 Cromwell Rd,
London, SW7 4DN
United Kingdom
